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| Player | Team | Date | Inn. | Count | Type | Dist. (ft.) | Field | Opponent | Home/Away | Pitcher | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| David Ortiz | Opponent | Sep 04, 2000 | 4 | N/A | Solo | N/A | N/A | Minnesota Twins | Away | Jose Mercedes | Win |
| David Ortiz | Opponent | Aug 06, 2002 | 6 | 0-0 | Two-run | N/A | Right-center | Minnesota Twins | Home | Sidney Ponson | Win |
| David Ortiz | Opponent | Aug 13, 2002 | 6 | 3-1 | Solo | N/A | Right | Minnesota Twins | Away | Scott Erickson | Loss |
| David Ortiz | Opponent | Aug 03, 2003 | 6 | 2-2 | Solo | N/A | Left-center | Boston Red Sox | Home | Rick Helling | Loss |
| David Ortiz | Opponent | Aug 03, 2003 | 8 | 2-2 | Solo | N/A | Center | Boston Red Sox | Home | Kerry Ligtenberg | Loss |
| David Ortiz | Opponent | Sep 09, 2003 | 3 | 2-2 | Two-run | 430 | Right | Boston Red Sox | Home | Damian Moss | Loss |
| David Ortiz | Opponent | Sep 22, 2003 | 8 | 1-1 | Solo | N/A | Center | Boston Red Sox | Away | Kerry Ligtenberg | Loss |
| David Ortiz | Opponent | Sep 23, 2003 | 10 | 2-1 | Solo | N/A | Left | Boston Red Sox | Away | Kurt Ainsworth | Loss |
| David Ortiz | Opponent | Sep 24, 2003 | 4 | 1-0 | Solo | N/A | Right | Boston Red Sox | Away | Pat Hentgen | Win |
| David Ortiz | Opponent | Sep 24, 2003 | 7 | 0-0 | Solo | N/A | Left | Boston Red Sox | Away | Pat Hentgen | Win |
| David Ortiz | Opponent | Apr 07, 2004 | 6 | 0-0 | Three-run | 371 | Right | Boston Red Sox | Home | Rick Bauer | Loss |
| David Ortiz | Opponent | Jul 28, 2004 | 9 | 2-2 | Solo | 390 | Center | Boston Red Sox | Home | B.J. Ryan | Win |
| David Ortiz | Opponent | Sep 20, 2004 | 4 | 0-1 | Two-run | N/A | Right | Boston Red Sox | Away | Matt Riley | Win |
| David Ortiz | Opponent | Sep 22, 2004 | 7 | 2-2 | Two-run | N/A | Center | Boston Red Sox | Away | Sidney Ponson | Loss |
| David Ortiz | Opponent | Oct 01, 2004 | 9 | 1-0 | Three-run | 415 | Right-center | Boston Red Sox | Home | John Parrish | Loss |
| David Ortiz | Opponent | Jun 02, 2005 | 9 | 3-2 | Three-run | N/A | Center | Boston Red Sox | Away | B.J. Ryan | Loss |
| David Ortiz | Opponent | Sep 03, 2005 | 7 | 0-1 | Solo | N/A | Center | Boston Red Sox | Away | Jorge Julio | Loss |
| David Ortiz | Opponent | May 17, 2006 | 9 | 1-1 | Two-run | 406 | Left-center | Boston Red Sox | Home | Chris Ray | Win |
| David Ortiz | Opponent | Jul 31, 2007 | 3 | 0-0 | Two-run | N/A | Right | Boston Red Sox | Away | Erik Bedard | Win |
| David Ortiz | Opponent | Jul 31, 2007 | 8 | 1-1 | Solo | N/A | Right-center | Boston Red Sox | Away | Rob Bell | Win |
| David Ortiz | Opponent | Aug 31, 2007 | 1 | 1-1 | Solo | N/A | Right | Boston Red Sox | Away | Radhames Liz | Win |
| David Ortiz | Opponent | Sep 06, 2007 | 5 | 3-2 | Solo | 380 | Right | Boston Red Sox | Home | Rocky Cherry | Loss |
| David Ortiz | Opponent | Sep 08, 2007 | 1 | 1-0 | Two-run | 395 | Right-center | Boston Red Sox | Home | Jon Leicester | Win |
| David Ortiz | Opponent | May 31, 2008 | 3 | 1-1 | Solo | 410 | Center | Boston Red Sox | Home | Garrett Olson | Loss |
| David Ortiz | Opponent | Jul 24, 2009 | 1 | 1-0 | Three-run | N/A | Center | Boston Red Sox | Away | Jeremy Guthrie | Loss |
