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| Player | Team | Date | Inn. | Count | Type | Dist. (ft.) | Field | Opponent | Home/Away | Pitcher | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Brian Roberts | Orioles | Jul 03, 2005 | 3 | 1-0 | Solo | 371 | Left | Cleveland Indians | Home | Cliff Lee | Loss |
| Rafael Palmeiro | Orioles | Jul 08, 2005 | 8 | 3-1 | Solo | 386 | Right | Boston Red Sox | Home | Bronson Arroyo | Loss |
| Rafael Palmeiro | Orioles | Jul 20, 2005 | 4 | 2-1 | Two-run | 383 | Right | Minnesota Twins | Away | Brad Radke | Loss |
| Jay Gibbons | Orioles | Jul 25, 2005 | 6 | 0-1 | Solo | 390 | Right-center | Texas Rangers | Home | Ron Mahay | Loss |
| Miguel Tejada | Orioles | Jul 27, 2005 | 1 | 1-1 | Three-run | 375 | Left | Texas Rangers | Home | Chris Young | Loss |
| Sammy Sosa | Orioles | Jul 27, 2005 | 1 | 2-1 | Solo | 345 | Right | Texas Rangers | Home | Chris Young | Loss |
| Javy Lopez | Orioles | Jul 27, 2005 | 9 | 0-0 | Two-run | 364 | Left | Texas Rangers | Home | Francisco Cordero | Loss |
| Rafael Palmeiro | Orioles | Jul 30, 2005 | 6 | 0-0 | Two-run | 345 | Right | Chicago White Sox | Home | Jose Contreras | Loss |
| Brian Roberts | Orioles | Jul 31, 2005 | 7 | 0-1 | Solo | 333 | Right | Chicago White Sox | Home | Freddy Garcia | Loss |
| Eric Byrnes | Orioles | Jul 31, 2005 | 7 | 2-1 | Solo | 360 | Left | Chicago White Sox | Home | Freddy Garcia | Loss |
| Javy Lopez | Orioles | Aug 23, 2005 | 4 | 2-2 | Solo | 371 | Left | Los Angeles Angels | Home | Jarrod Washburn | Loss |
| Miguel Tejada | Orioles | Aug 23, 2005 | 8 | 3-2 | Solo | 368 | Right | Los Angeles Angels | Home | Scot Shields | Loss |
| Miguel Tejada | Orioles | Aug 23, 2005 | 9 | 1-2 | Grand slam | 340 | Right | Los Angeles Angels | Home | Francisco Rodriguez | Loss |
| Melvin Mora | Orioles | Aug 27, 2005 | 4 | 3-1 | Solo | 379 | Left-center | Oakland Athletics | Home | Joe Kennedy | Loss |
| David Newhan | Orioles | Aug 28, 2005 | 6 | 3-2 | Solo | 390 | Center | Oakland Athletics | Home | Danny Haren | Loss |
| Melvin Mora | Orioles | Aug 28, 2005 | 9 | 0-0 | Solo | 398 | Left | Oakland Athletics | Home | Ron Flores | Loss |
| Jay Gibbons | Orioles | Aug 29, 2005 | 6 | 1-0 | Solo | 370 | Right | Oakland Athletics | Home | Ricardo Rincon | Loss |
| Brian Roberts | Orioles | Aug 30, 2005 | 1 | 1-0 | Solo | 360 | Right | Toronto Blue Jays | Away | David Bush | Loss |
| Melvin Mora | Orioles | Sep 24, 2005 | 7 | 2-1 | Two-run | 368 | Left | Boston Red Sox | Home | Craig Hansen | Loss |
| Melvin Mora | Orioles | Sep 25, 2005 | 1 | 3-2 | Solo | 388 | Left | Boston Red Sox | Home | David Wells | Loss |
| Miguel Tejada | Orioles | Sep 25, 2005 | 1 | 0-0 | Solo | 392 | Center | Boston Red Sox | Home | David Wells | Loss |
| Eddie Rogers | Orioles | Sep 26, 2005 | 9 | 0-1 | Solo | 348 | Left | New York Yankees | Home | Alan Embree | Loss |
| Javy Lopez | Orioles | Sep 28, 2005 | 2 | 2-0 | Solo | 378 | Left | New York Yankees | Home | Shawn Chacon | Loss |
| Javy Lopez | Orioles | Sep 29, 2005 | 7 | 1-0 | Two-run | 367 | Left | New York Yankees | Home | Aaron Small | Loss |
| Jay Gibbons | Orioles | Sep 29, 2005 | 8 | 0-0 | Two-run | 393 | Center | New York Yankees | Home | Tanyon Sturtze | Loss |
