| Player | Team | Date | Inn. | Count | Type | Dist. (ft.) | Field | Opponent | Home/Away | Pitcher | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Evan Longoria | Opponent | Apr 06, 2010 | 6 | 2-2 | Solo | 473 | Left | Tampa Bay Rays | Away | Kevin Millwood | Loss |
| Evan Longoria | Opponent | Apr 07, 2010 | 8 | 1-0 | Solo | N/A | Left-center | Tampa Bay Rays | Away | Cla Meredith | Loss |
| Alex Gonzalez | Opponent | Apr 09, 2010 | 3 | 0-0 | Solo | 409 | Left-center | Toronto Blue Jays | Home | Brad Bergesen | Loss |
| Alex Gonzalez | Opponent | Apr 11, 2010 | 4 | 0-0 | Solo | 403 | Left | Toronto Blue Jays | Home | Kevin Millwood | Loss |
| Jose Bautista | Opponent | Apr 11, 2010 | 8 | 1-2 | Two-run | 356 | Left | Toronto Blue Jays | Home | Kevin Millwood | Loss |
| Alex Gonzalez | Opponent | Apr 11, 2010 | 8 | 2-2 | Solo | 344 | Left | Toronto Blue Jays | Home | Kevin Millwood | Loss |
| Edwin Encarnacion | Opponent | Apr 11, 2010 | 9 | 3-1 | Solo | 400 | Left | Toronto Blue Jays | Home | Cla Meredith | Loss |
| Reid Brignac | Opponent | Apr 12, 2010 | 3 | 0-2 | Solo | 345 | Right | Tampa Bay Rays | Home | Jeremy Guthrie | Loss |
| Carl Crawford | Opponent | Apr 12, 2010 | 8 | 2-1 | Solo | 402 | Right | Tampa Bay Rays | Home | Mark Hendrickson | Loss |
| Carlos Pena | Opponent | Apr 13, 2010 | 10 | 2-2 | Three-run | 365 | Right | Tampa Bay Rays | Home | Matt Albers | Loss |
| Carlos Pena | Opponent | Apr 14, 2010 | 1 | 0-0 | Three-run | 408 | Left-center | Tampa Bay Rays | Home | Brad Bergesen | Loss |
| B.J. Upton | Opponent | Apr 14, 2010 | 3 | 1-1 | Three-run | 405 | Left-center | Tampa Bay Rays | Home | Brad Bergesen | Loss |
| B.J. Upton | Opponent | Apr 14, 2010 | 7 | 0-2 | Solo | 395 | Center | Tampa Bay Rays | Home | Jason Berken | Loss |
| Casey Kotchman | Opponent | Apr 19, 2010 | 3 | 1-1 | Two-run | N/A | Right | Seattle Mariners | Away | Brad Bergesen | Loss |
| David Ortiz | Opponent | Apr 23, 2010 | 2 | 2-1 | Solo | N/A | Left-center | Boston Red Sox | Away | Jeremy Guthrie | Loss |
| Jason Varitek | Opponent | Apr 24, 2010 | 5 | 2-0 | Solo | N/A | Left-center | Boston Red Sox | Away | Brian Matusz | Loss |
| Marco Scutaro | Opponent | Apr 24, 2010 | 7 | 0-0 | Three-run | N/A | Left | Boston Red Sox | Away | Matt Albers | Loss |
| Kevin Youkilis | Opponent | Apr 24, 2010 | 7 | 0-1 | Three-run | N/A | Left | Boston Red Sox | Away | Kam Mickolio | Loss |
| Jorge Posada | Opponent | Apr 27, 2010 | 4 | 0-1 | Solo | N/A | Right | New York Yankees | Home | Kevin Millwood | Win |
| Robinson Cano | Opponent | Apr 28, 2010 | 3 | 0-0 | Solo | 395 | Right-center | New York Yankees | Home | Jeremy Guthrie | Loss |
| Robinson Cano | Opponent | Apr 29, 2010 | 4 | 1-0 | Solo | 399 | Right-center | New York Yankees | Home | Brian Matusz | Loss |
| Robinson Cano | Opponent | Apr 29, 2010 | 8 | 0-1 | Solo | 370 | Right | New York Yankees | Home | Alberto Castillo | Loss |
| J.D. Drew | Opponent | Apr 30, 2010 | 2 | 0-1 | Solo | 382 | Left-center | Boston Red Sox | Home | David Hernandez | Win |
| Dustin Pedroia | Opponent | Apr 30, 2010 | 6 | 0-1 | Solo | 361 | Right | Boston Red Sox | Home | David Hernandez | Win |
| J.D. Drew | Opponent | Apr 30, 2010 | 8 | 2-2 | Solo | 402 | Center | Boston Red Sox | Home | Jim Johnson | Win |
